That depends on the angle at which you sit. If you sit in a straight chair, yes, it's gonna be a bitch on the neck. But if you sit in a recliner or a laid back sorta chair, then it's all good.
I say it all depends on the seated position of the watcher. In my first apartment, I attached the TV to the ceiling in the bedroom. While laying in bed it was great. You could lay back without propping yourself up on a stack of pillows.
In my living room now, there is a 60" sitting on top of the mantle of a defunct fireplace. I used the hearth as an area for the electronics. I built shelving and cut the appropriate holes for the wires. I don't have the high dollar wireless stuff yet. As long as this stuff works, I don't need any more than 1500 watts of audio.